Publication Details




In Vitro And Computational Fluid Dynamics Comparison Of The Flow Diversion Efficacy Of Five Commercial Stents


Ronak J. Dholakia, Andrew Pagano, Fotios Drakopoulos, Ari Kappel, Chander Sadasivan, Xiangmin Jiao,, David J. Fiorella, Nikos Chrisochoides, Henry H. Woo and Baruch B. Lieber.


Published in Summer Biomechanics, Bioengineering, and Biotransport Conference, June, 2015




Brain aneurysms are abnormal ballooning of intracranial arteries which when left untreated may result in fatal outcome for the patients. Neurovascular stents have been used extensively in stent-assisted coiling treatment of aneurysms. Treatment with flow diverters (low porosity, fine-mesh stents) is used for complicated aneurysm geometries not amenable to coiling. Angiographic analysis with mathematical modeling has been applied for comparison of different flow diversion designs as well as towards prediction of flow diversion efficacy [1]. High resolution computational fluid dynamics (CFD) simulations would provide the opportunity to study localized alterations in hemodynamics due to different devices. Current class of CFD studies with flow diverters in cerebral aneurysm models do not use realistic wire configurations in their models and the fine differences in porosity and pore density across the aneurysm neck might produce inaccurate results. The proposed study aims to test five commercially available neurovascular devices that have not been compared before through angiographic washout analysis and accurate microCT-based mesh reconstruction and CFD analysis in idealized sidewall aneurysm models.




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