Medical Image Non-Rigid Registration (NRR)


Image Guided Neurosurgery (IGNS) is different from conventional neurosurgery by the availability of imaging which helps surgeon to understand what is going on inside the patient's brain while the tissue resection is underway. The major advantage of this is that the surgeon can avoid the critical regions of the brain, as they shift due to changing conditions as the surgery goes on. Thus, there is a better possibility for good outcome of the operation and improved quality of his or her life afterwards.

Non-rigid registration is one of the enabling technologies for IGNS. As the surgery progresses, the brain changes its shape and shifts. Thus, multimodal imaging data acquired prior to the surgery becomes invalid. During IGNS brain deformation is tracked by acquiring low resolution MRI in an open MR scanner, which is subsequently used to deform, or register, the preoperative data.

Preop Intraop
Preoperative MRI Intraoperative MRI


Volumetric registration of MRI using intraoperative imaging has long been too computationally expensive to be practical. Our distributed implementation of non-rigid registration, for the first time, enabled in-time delivery of registration results to the surgeons. The implementation we have developed is able to span multiple computational sites distributed geographically, and communicate the results back to to operating room.

Neurosurgery 1 Deformation overlay
Deformation field is computed using intraoperative image
and mesh-based biomechanical model.